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KMID : 0191120000150030323
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Journal of Korean Medical Science
2000 Volume.15 No. 3 p.323 ~ p.326
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Effects of oncostatin M on hormone release of rat pituitary cells in primary culture
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Kim DS
Choi HS/Park YS/Kim TW
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Abstract
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It has become increasingly clear that cytokines play an important role in modulating neuroendocrine
regulation, especially in the secretion of corticotropin (ACTH) in the pituitary. Oncostatin M (OSM),
a cytokine of IL-6 family has been reported to increase ACTH secretion and pro-opiomelanocortin (POMC)
transcription in murine corticotroph pituitary tumor cells (AtT20 cells). The present study was undertaken
to determine the effects of OSM on hormonal release in primary culture of rat pituitary cells. Growth
hormone or prolactin release was not affected by OSM. OSM (1 nM) stimulated ACTH release (35.1% increase
versus control, p<0.001) in dispersed pituitary cells of rat to a lesser extent than in AtT20 cells.
Corticotropin releasing hormone (CRH) (10 nM) also induced a 2.3-fold increase of ACTH secretion (p<0.001),
but co-treatment of OSM and CRH did not exhibit any synergistic effect on ACTH secretion. We conclude OSM
has a stimulatory effect on ACTH secretion in normal rat pituitary cell cultures, and OSM acts mainly on
corticotroph, supporting the potential role of OSM to modulate immune-endocrine regulation in the pituitary.
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KEYWORD
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